This is not a red flag. This is a red floodlight.

But not every limitation is this obvious. Some barriers announce themselves in bold print on the first page of the schedule of assessments. Others hide in a single line buried in an appendix--a required CLIA-waived laboratory certification your site does not hold, a PET/CT scan your nearest imaging center cannot perform with the protocol-specified radiotracer, a participant population that requires a diagnosis your practice simply does not see. The operational review you completed in the previous lesson made the protocol's demands visible. Now you must evaluate those demands against your site's actual capabilities and sort the results into categories that drive different decisions.

This lesson is about that sorting. It is about developing the analytical discipline to distinguish between limitations that kill a study at your site and limitations that merely require work to overcome. And it is about communicating those findings in a way that demonstrates professional rigor rather than institutional insecurity.

This is not a red flag. This is a red floodlight.

But not every limitation is this obvious. Some barriers announce themselves in bold print on the first page of the schedule of assessments. Others hide in a single line buried in an appendix--a required CLIA-waived laboratory certification your site does not hold, a PET/CT scan your nearest imaging center cannot perform with the protocol-specified radiotracer, a participant population that requires a diagnosis your practice simply does not see. The operational review you completed in the previous lesson made the protocol's demands visible. Now you must evaluate those demands against your site's actual capabilities and sort the results into categories that drive different decisions.

This lesson is about that sorting. It is about developing the analytical discipline to distinguish between limitations that kill a study at your site and limitations that merely require work to overcome. And it is about communicating those findings in a way that demonstrates professional rigor rather than institutional insecurity.