Decentralized and hybrid trial designs: the CRC's evolving role
Explain how decentralized and hybrid trial designs change CRC responsibilities including remote visit management, home health coordination, direct-to-participant shipments, telehealth integration, and the new communication skills required when participants are not physically present at the site.
The trial that left the building
The protocol lands in the coordinator's inbox on a Wednesday morning, and something about it feels different. The Phase III autoimmune study requires participants to complete screening and randomization at the site -- that part is familiar. But after randomization, the protocol shifts. Participants receive their study medication via overnight courier, shipped directly to their homes from a specialty pharmacy. Monthly vital signs assessments are captured by a Bluetooth-connected blood pressure monitor and a wearable activity tracker, both of which upload data directly to the electronic data capture system. Telehealth visits replace two of every three in-person visits. Home health nurses draw quarterly blood samples at the participant's kitchen table. The participant comes to the site once every 12 weeks.